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Strong lipid mediators, leukotrienes (LTs), such as cysteinyl LTs (CysLTs) and LTB4, play a key role in the pathogenesis of asthma symptoms. There are at least two known receptor subtypes for CysLTs: CysLT1 and CysLT2. The activation of the CysLT1 receptor mediates the majority of the pathophysiological consequences of CysLTs in asthma, such as increased airway smooth muscle activity, microvascular permeability, and airway mucus secretion. Asthma exacerbations, severe asthma, and airway hyperresponsiveness may all be influenced by LTB4. CysLT1 receptor antagonists can be administered orally as monotherapy in patients with persistent mild asthma, despite the fact that they are typically less efficacious than inhaled glucocorticoids. CysLT1 receptor antagonists can be used in conjunction with inhaled glucocorticoids for people withmore severe asthma. By using this therapeutic approach, asthma can be better controlled and the amount of glucocorticoid that is inhaled can be decreased without sacrificing effectiveness. Since the sensitivity to CysLT1 receptor antagonists varies, it is important to identify subgroups of asthmatic patients who react to these medications in order to treat their condition. CysLT1 receptor antagonists' possible anti-remodeling action may be crucial for stopping or undoing structural alterations in asthmatic airways. The function of LTs in asthma is covered in this review, along with the potential therapeutic benefits of pharmacologically modifying the LT pathway.

  • Read count 14
  • Date of publication 10-05-2025
  • Main LanguageIngliz
  • Pages208-215
English

Strong lipid mediators, leukotrienes (LTs), such as cysteinyl LTs (CysLTs) and LTB4, play a key role in the pathogenesis of asthma symptoms. There are at least two known receptor subtypes for CysLTs: CysLT1 and CysLT2. The activation of the CysLT1 receptor mediates the majority of the pathophysiological consequences of CysLTs in asthma, such as increased airway smooth muscle activity, microvascular permeability, and airway mucus secretion. Asthma exacerbations, severe asthma, and airway hyperresponsiveness may all be influenced by LTB4. CysLT1 receptor antagonists can be administered orally as monotherapy in patients with persistent mild asthma, despite the fact that they are typically less efficacious than inhaled glucocorticoids. CysLT1 receptor antagonists can be used in conjunction with inhaled glucocorticoids for people withmore severe asthma. By using this therapeutic approach, asthma can be better controlled and the amount of glucocorticoid that is inhaled can be decreased without sacrificing effectiveness. Since the sensitivity to CysLT1 receptor antagonists varies, it is important to identify subgroups of asthmatic patients who react to these medications in order to treat their condition. CysLT1 receptor antagonists' possible anti-remodeling action may be crucial for stopping or undoing structural alterations in asthmatic airways. The function of LTs in asthma is covered in this review, along with the potential therapeutic benefits of pharmacologically modifying the LT pathway.

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