The relevance of the problem under study is due to the high prevalence of drug-resistant epilepsy, an increase in the detection of structural lesions in its etiology and an expansion of indications for surgical treatment.The purpose of the article is to study the causes of unsatisfactory effectiveness of surgical treatment of drug-resistant epilepsy in the adult population from the standpoint of an interdisciplinary approach in order to determine the ways of comprehensive optimization of treatment results.Material and methods. The leading approach to the study of this problem is a retrospective open cohort study of surgical treatment outcomes in 36 patients with analysis of adverse outcome factors in 14 individuals.Results. It was revealed that unsatisfactory outcomes of surgical treatment of epilepsy are due to a combination of reasons. Disease features were the main cause of adverse outcome in 100% of cases, irrational pharmacotherapy additionally complicated the course of the disease in 86% of cases, and surgical reasons in 36% of cases.Conclusions. Unsatisfactory outcomes of surgical treatment of epilepsy are due to a combination of reasons. An interdisciplinary approach to the problem, improved organization of epileptological care, and further studies of predictors of outcomes of surgical treatment of epilepsy are required. The materials of the article may be useful for developing a personalized approach to the surgical treatment of epilepsy
The relevance of the problem under study is due to the high prevalence of drug-resistant epilepsy, an increase in the detection of structural lesions in its etiology and an expansion of indications for surgical treatment.The purpose of the article is to study the causes of unsatisfactory effectiveness of surgical treatment of drug-resistant epilepsy in the adult population from the standpoint of an interdisciplinary approach in order to determine the ways of comprehensive optimization of treatment results.Material and methods. The leading approach to the study of this problem is a retrospective open cohort study of surgical treatment outcomes in 36 patients with analysis of adverse outcome factors in 14 individuals.Results. It was revealed that unsatisfactory outcomes of surgical treatment of epilepsy are due to a combination of reasons. Disease features were the main cause of adverse outcome in 100% of cases, irrational pharmacotherapy additionally complicated the course of the disease in 86% of cases, and surgical reasons in 36% of cases.Conclusions. Unsatisfactory outcomes of surgical treatment of epilepsy are due to a combination of reasons. An interdisciplinary approach to the problem, improved organization of epileptological care, and further studies of predictors of outcomes of surgical treatment of epilepsy are required. The materials of the article may be useful for developing a personalized approach to the surgical treatment of epilepsy
| № | Author name | position | Name of organisation |
|---|---|---|---|
| 1 | Abduvoyitov B.. | ! | Samarkand State Medical University |
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| 1 | 1.Zenkov LR. Clinical epileptology with elements of neurophysiology. Guidelines for doctors. M.: Medical information Agency, 2010. p.408. In Russian. 2.Zotov YuV, Kasumov RD, Stepanova TS, et al. Differentiated tactics of surgical treatment of traumatic epilepsy. Proceedings of the III Congress of the neurosurgery 2002; 466-467. In Russian. [Zotov Yu.V., Kasumov R.D., Stepanova T.S., et al. Differentiated tacticsof surgical treatment of traumatic epilepsy. Proc . III Congress of Neurosurgeons. 2002; 466-467].3.Krylov VV, Guekht AB, Trifonov IS. Outcomes of surgical treatment of patients with pharmacoresistance epilepsy. Journal of neurology and psychiatry. 2016; 9(2): 13–18. In Russian. [KrylovV. V. , HechtA . B. , Trifonov I.S., and[Outcomes of surgical treatment in patients with drug-resistant forms of epilepsy. J Neurol Psychiatry. 2016; 9(2): 13–18]. 4.Lowe NM, Eldridge P, Varma T, WieshmannUC. The duration of temporal lobe epilepsy and seizure outcome after epilepsy surgery. Seizure. 2010;19 (5):261–263. 5.Janszky J, Janszky I, Schulz R, et al. Temporal lobe epilepsy with hippocampal sclerosis: predictors for long-term surgical outcome. Brain. 2005;128 (Pt 2):395–404. 6.Téllez-Zenteno JF, Hernández Ronquillo L, et al . Surgical outcomes in lesional and non-lesional epilepsy: a systematic review and meta-analysis. Epilepsy Res. 2010; 89(2-3):310-308. 7.Odintsova GV, Kuralbaev AK, Nezdorovina VG. Surgical treatment of temporal epilepsy: problems and effectiveness (a clinical case). Epilepsy and paroxysmalconditions. 2017; 9(2):41-49. In Russian.8.Abduvoyitov, B. (2025). FARMAKOREZISTENT EPILEPSIYA BILAN OG'RIGAN BEMORLARNING JARROHLIK DAVOLASH NATIJALARI VA QONIQARSIZ JARROHLIK NATIJALARINI BASHORAT QILUVCHI OMILLAR. Modern Science and Research, 4(2), 91-92.9.Abduvoyitov, B. (2025). POLIMIKROGIRIYALI FARMAKOREZISTENT EPILEPSIYANI DAVOLASH NATIJALARI. Modern Science and Research, 4(2), 117-121.10.Abduvoyitov, B. (2025). FARMAKOREZISTENT EPILEPSIYADA STEROIDLARNING AHAMIYATI. Medical Research Journal, 1(1), 244-250 |